At 31 years old, Frances Bean Cobain has this physical status:
In August 2006, she was photographed for Elle UK magazine in her father's famous brown cardigan and pajama pants as part of an article featuring children of rock stars in their parents' clothing. She explained, "I wore his pajamas because he got married in them to my mom in 1992 in Hawaii so I thought they would be cute if I wore them today. He was too lazy to put on a tux so he got married in pajamas!" In February 2008, she appeared in a photo spread for Harper's Bazaar dressed as Evita. Cobain modeled for Hedi Slimane for a web photo series released August 2, 2011. In 2016, she modeled alongside Alice Glass in a spread for Schön! magazine shot by Floria Sigismondi. In 2017, she was announced as the face of Marc Jacobs's Spring/Summer campaign for that year, shot by David Sims.
In July 2010, Cobain debuted a collection of artwork titled Scumfuck under the pseudonym "Fiddle Tim" at the La Luz de Jesus Gallery in Los Angeles. On August 4, 2012, she participated in the group show 'MiXTAPE' under her real name. Artists were asked to pick a song and create art inspired by that song. Cobain chose the song "Black" by The Jesus and Mary Chain. The eclectic mix of songs chosen were featured for digital download on iTunes. Opening on June 7, 2017, through June 30, Cobain and artist Lindsey Way held a joint art exhibition titled "Ghosts For Sale" at Gallery 30 South in Pasadena.
According to Rolling Stone magazine, the title and cover photograph for the 2005 Nirvana rarities album Sliver: The Best of the Box were chosen by 13-year old Cobain. Cobain worked as an intern for Rolling Stone magazine from June to August 2008. She was featured in the magazine years later, photographed by David LaChapelle. In 2009, it was reported that Cobain had turned down the role of Alice in Tim Burton's film Alice in Wonderland.
Cobain appeared as a guest vocalist on the song "My Space" from the album Evelyn Evelyn by Evelyn Evelyn, which was released on March 30, 2010. Amanda Palmer from Evelyn clarified that Cobain was one of some 20 artists who sang the same line and whose voices were mixed together in the recording. Cobain was also an executive producer on the HBO movie about her father's life, Kurt Cobain: Montage of Heck. In 2019, she appeared as a special guest judge in one episode of RuPaul's Drag Race All Stars season 4.