At 24 years old, Willow Hand has this physical status:
Hand's first fashion show was opening for Prada for whom she was a debut exclusive at the Autumn/Winter 2015 Milan Fashion Week. The following week, she was at Paris Fashion Week where she walked for Miu Miu.
In 2015, she was named by Elle Magazine as one of eight breakout stars. She was listed as one of fifteen up-and-coming American models to watch.
She has walked the runway for Prada, Miu Miu, Gucci, Louis Vuitton, Anna Sui, Valentino, Chanel, Dolce and Gabbana, Fendi, Alexander McQueen, Vera Wang, Diane von Fürstenberg, Zac Posen, Tory Burch, Carolina Herrera, Prabal Gurung, John Galliano, Thakoon, Sonia Rykiel, Missoni, Oscar De La Renta, Tommy Hilfiger, Victoria Beckham, Chloé, Rochas, Jil Sander, Fausto Puglisi, Fay, Paco Rabanne, Maison Margiela, DSquared2, MSGM, Philosophy di Alberta Ferretti, Giambattista Valli, Roberto Cavalli, Francesco Scognamiglio, No 21, Mary Katrantzou, Michael Kors, Rodarte, and Topshop.
She has done campaigns for Prada, Anna Sui, Bottega Venetta, Zara, Benetton, Jill Stuart and Victoria's Secret Pink. Hand was chosen to be featured by Free People as a Muse and shot for their catalogue.
She has been in editorials for Vogue Paris, British Vogue, Vogue Italia, Teen Vogue, Vogue Russia, Vogue Japan, Vogue Ukraine, Vogue China, Vogue Mexico, Vogue Spain, Vogue Thailand, Allure, Russh, Garage, Dazed, Numero Tokyo, and In Print magazine.
In 2018, Hand walked for Victoria's Secret Fashion Show 2018.
Her look has been compared to that of a Disney princess.