At 39 years old, Lara Stone has this physical status:
Stone left Elite and signed with IMG Models worldwide in 2006. In January, she made her catwalk debut when Riccardo Tisci put her in his Givenchy couture shows during the Paris Fashion Week. Later that year, she was an exclusive for Calvin Klein. In 2007, she was the subject of a spread in March's Vogue Paris in the style of Brigitte Bardot and also appeared on the cover of the April issue. The New York Times' fashion critic Cathy Horyn named her the "anti-model" in her On the Runway blog; describing her as "not your typical catwalk android with her gapped front teeth, stunned expression, and Lurch walk, which can be attributed to her small size 7 feet – catwalk shoes are at least a size larger." New York Magazine to rank her No. 2 on their "Top Ten Models to Watch" for in New York Fashion Week.
Stone has opened shows for Giles Deacon, Isabel Marant, Christopher Kane, Fendi, and MaxMara, and closed for Chanel, Diesel, Marc Jacobs, Stella McCartney, and Balmain. She has also been a "semi-exclusive" for Prada, meaning she could not walk any other shows during New York fashion week or any shows in Milan before the Prada show.
Her spring/summer 2008 campaigns included Givenchy, Belstaff, Just Cavalli, and H&M. Her campaigns for autumn/winter 08 included Calvin Klein, Givenchy, Belstaff, Hugo Boss, Calvin Klein Cosmetics, and Jil Sander. Stone was one of the models chosen to be in one of the fourteen covers of V magazine September 2008 issue. Shot by Inez van Lamsweerde and Vinoodh Matadin, each cover has a headshot of a model, either from the newer generation of models or the supermodel era.
Stone was also photographed alongside Małgosia Bela, Daria Werbowy, Randal Moore, Mariacarla Boscono, Emanuela de Paula, and Isabeli Fontana for the 2009 Pirelli Calendar.
In the February 2009 edition of Vogue Paris, which featured Stone on the cover, she said she does not like the runway and that her unusually small feet for a person her size do not fit in shoes. Stone was featured on the August 2009 cover of W, declaring her "Fashion's It Girl" and the reasons she is the most-wanted face and body in the business. Vogue Paris named her as one of the top 30 models of the 2000s. Stone made her American Vogue debut on the May 2009 cover alongside Liya Kebede, Anna Jagodzinska, Natalia Vodianova, Caroline Trentini, Jourdan Dunn, Raquel Zimmermann, Sasha Pivovarova, Natasha Poly, Karen Elson, and Isabeli Fontana as one of the "Faces of the Moment". It was also a special issue because the cover featured models instead of celebrities. An international racial controversy arose when she appeared in an editorial for French's Vogue October 2009 issue with her face and body blackened.
In 2010, Stone replaced Sasha Pivovarova as the new face for Prada's fragrance Infusion d'Iris, shot by Steven Meisel. Her other spring/summer campaigns included Louis Vuitton, Versus by Versace Fragrance, Jaeger, and H&M. This same year her look sparked a trend in blonde, gap-toothed, big-lipped models like Georgia May Jagger, Lindsey Wixson, and Ashley Smith. The look even inspired Tyra Banks to have a contestant's tooth gap widened on cycle 15 of America's Next Top Model.
Stone signed an exclusive deal with Calvin Klein Inc., making the 26-year-old model the face of Calvin Klein Collection, CK Calvin Klein, and Calvin Klein Jeans for fall 2010. It marked the first time in years the fashion house had chosen to use one model for three of its brands, and Stone would be exclusive to CKI for all apparel advertising and runway appearances for fall. Ending the year she won British Fashion Awards' Model of the year 2010.
Stone was featured in the 2011 Pirelli Calendar photographed by Karl Lagerfeld. Stone was part Vogue UK's first multi-cover in the publication's 95-years, landing one of the three May 2011 covers in celebration of the Wedding of Prince William of Wales and Kate Middleton. She debuted on Forbes' World's Top-Earning Models list, ranking No. 7, with estimated earnings of $4.5 million since May of last year (2010–2011).
Stone was again featured in the 2012 Pirelli Calendar photographed by Mario Sorrenti and also as the face of Calvin Klein's 2012 Underwear campaign.
Stone was ranked #1 on models.com's "Top 50 Models" list from Spring 2010 to Summer 2012 before moving to their "Industry Icons" list and she was also ranked the 9th sexiest model on their Top Sexiest Models list.
In March 2014, Stone again appeared on the cover of Vogue Paris and in April, American Harper's Bazaar.
In March 2015, Stone appeared on one of three Vogue Paris covers alongside Kate Moss and Daria Werbowy. Stone was also on the August cover of British Vogue, shot by Mario Testino.
In 2016, Stone made a cameo appearance in Mandie Fletcher's Absolutely Fabulous: The Movie.
Stone starred with Yvan Attal, Mathilde Bisson, Arthur Igual and Akaji Maro in the short film En Moi ("In Me") directed by Laetitia Casta. The film was selected for the closing ceremony of the 2016 Cannes Film Festival Critic's Week.