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- Isaac Newton Skelton IV (December 20, 1931 – October 28, 2013) was an American politician who was the U.S. Representative for Missouri's 4th congressional district from 1977 to 2011.
- During his tenure, he served as the chairman of the House Armed Services Committee.
- He was a member of the Democratic Party.
- On November 2, 2010, he lost his seat to Republican Vicky Hartzler amid a Republican wave.
- Notably, he was one of three Democratic committee chairmen to lose reelection in the 2010 midterm cycle, alongside House Budget Committee chairman John Spratt of South Carolina and House Transportation and Infrastructure Committee chairman Jim Oberstar of Minnesota.