At 47 years old, David Oyelowo has this physical status:
He began his stage career in 1999 when he was offered a season with the Royal Shakespeare Company playing roles in Ben Jonson's Volpone, as the title character in Oroonoko (which he also performed in the BBC radio adaptation) and Shakespeare's Antony and Cleopatra (1999) alongside Guy Henry, Frances de la Tour and Alan Bates. However, he is best known for his next stage performance as King Henry VI in the Royal Shakespeare Company's 2001 productions of Shakespeare's trilogy of plays about the king as a part of its season This England: The Histories. In a major landmark for colour-blind casting, Oyelowo was the first black actor to play an English king in a major production of Shakespeare, and although this casting choice was initially criticised by some in the media, Oyelowo's performance was critically acclaimed and later won the 2001 Ian Charleson Award for best performance by an actor under 30 in a classical play.
In 2005, he appeared in a production of Prometheus Bound, which was revived in New York City in 2007. In 2006, he made his directorial debut on a production of The White Devil, produced by Inservice, his theatre company in Brighton which is co-run with fellow Brighton-based actors Priyanga Burford, Israel Aduramo, Penelope Cobbuld, and his wife, Jessica. He played the title role in Othello in 2016 at the New York Theatre Workshop with Daniel Craig as Iago, directed by Sam Gold.
Oyelowo is best known for playing MI5 officer Danny Hunter on the British drama series Spooks (known in North America as MI-5) from 2002 to 2004. He had before that appeared in Tomorrow La Scala (2002), Maisie Raine (1998) and Brothers and Sisters (1998). Soon after the end of his time on Spooks Oyelowo also appeared in the two Christmas specials of As Time Goes By (2005). In 2006, he appeared in the television film Born Equal alongside Nikki Amuka-Bird as a couple fleeing persecution in Nigeria – they also both appeared in Shoot the Messenger (2006) and in The No. 1 Ladies' Detective Agency (2008) as a husband and wife. Other cameos have included Mayo (guest-starring on 30 April 2006) and the television film Sweet Nothing in My Ear (2008, as defence attorney Leonard Grisham), while he has played recurring or main characters on Five Days (2007) and The Passion (2008, as Joseph of Arimathea).
In December 2009, he played the leading role of Gilbert in the BBC TV adaptation of Andrea Levy's novel Small Island. In March 2010, he played the role of Keme Tobodo in the BBC's drama series Blood and Oil. He starred in the HBO original film Nightingale (2014). He recently signed a deal with ViacomCBS.
He appeared as Olaudah Equiano in Grace Unshackled – The Olaudah Equiano Story, a radio play adapting Equiano's autobiography, The Interesting Narrative of the Life of Olaudah Equiano. This was first broadcast on BBC 7 on 8 April 2007, with his wife Jessica Oyelowo as Mrs. Equiano.
In 2007, Oyelowo was the reader for John le Carré's The Mission Song. AudioFile magazine stated: "Think of David Oyelowo as a single musician playing all the instruments in a symphony. That is essentially what he manages in this inspired performance of John le Carré's suspense novel.... Can it really have been only one man in the narrator's recording booth? This virtuoso performance makes that seem impossible." In 2015, he was selected to portray James Bond in an audiobook version of Trigger Mortis, written by Anthony Horowitz.
As of 2014, he provides the voice of Imperial Security Bureau agent Alexsandr Kallus on the animated series Star Wars Rebels. As of 2017, Oyelowo voices the spirit of Scar, the main antagonist in season 2 of The Lion Guard. Oyelowo voiced the Tiger in a television adaptation of The Tiger Who Came to Tea which aired on Channel 4 for Christmas 2019.
In 2012, Oyelowo appeared in Middle of Nowhere. Writer-director Ava DuVernay had been a fan of his work and had considered asking him to take the role, however before she could, Oyelowo received the script coincidentally from a friend of a friend of DuVernay's who happened to be sitting next to him on the plane and was considering investing in the project. The film premiered at the 2012 Sundance Film Festival to critical raves. That same year Oyelowo appeared in Lee Daniels' The Paperboy, which competed for the Palme d'Or at the 2012 Cannes Film Festival. Oyelowo reunited with Daniels the following year in The Butler.
In 2014, Oyelowo formed his own independent production company, Yoruba Saxon Productions which has co-produced movies that featured him including, Nightingale, Captive, Five Nights in Maine and most recently, A United Kingdom.
He worked with DuVernay again for Selma (2014), playing civil rights activist Martin Luther King Jr. The film, based on the 1965 Selma to Montgomery voting rights marches, had originally been set to be directed by Lee Daniels, but the project was dropped by Daniels so he could focus on The Butler.
He is slated to star with Lupita Nyong'o in a film adaptation of the Chimamanda Ngozi Adichie novel Americanah. The story follows a pair of young Nigerian immigrants who face a lifetime of struggle while their relationship endures.
In February 2019, it was announced that Oyelowo had joined the Peter Rabbit cast with James Corden, Rose Byrne and Domhnall Gleeson reprising their roles as the title character, Bea and Thomas McGregor for its sequel due to be released in March 2021.
In 2020, Oyelowo starred alongside George Clooney in the Netflix film The Midnight Sky. More recently, his Yoruba Saxon company signed a first look deal with Disney. The first film to come out of the deal will be The Return of the Rocketeer, a Disney+-exclusive sequel to the 1991 film The Rocketeer, which Oyelowo will produce alongside his wife, Jessica, and Brigham Taylor. Oyelowo is also being considered to star in the film, which will center on "a retired Tuskegee airman who takes up the Rocketeer mantle".