At 45 years old, Anthony Mackie has this physical status:
In 2002, Mackie worked as an understudy to Don Cheadle in Suzan-Lori Parks' play Topdog/Underdog and won an OBIE Award for his role in Carl Hancock Rux's play Talk. He appeared in the 2002 film 8 Mile as the main antagonist, Papa Doc. His first starring role in a feature film was the 2003 independent film Brother to Brother, where he played Perry, a young artist who struggles to adjust to the world as a gay black man. The following year, Mackie appeared in Million Dollar Baby, which won the Academy Award for Best Picture, and starred in Spike Lee's She Hate Me. In 2006, Mackie starred in Half Nelson, Crossover, and We Are Marshall.
In March 2008, Mackie starred in three plays by playwright August Wilson at the John F. Kennedy Center for the Performing Arts in Washington DC: Ma Rainey's Black Bottom, Fences, and Jitney – all part of "August Wilson's 20th Century", a month-long presentation of ten staged readings of Wilson's "Century Cycle". Mackie has participated several times in the "24-Hour Plays" held in New York City each fall. In mid-2009, he played the role of Pentheus in the New York City Public Theater's Shakespeare in the Park production of The Bacchae. He starred with Christopher Walken in A Behanding in Spokane on Broadway in February 2010.
Mackie portrayed late American rapper Tupac Shakur in the 2009 film Notorious. He had previously portrayed Shakur in the play Up Against the Wind in 2001, while attending Juilliard. In 2009, he appeared in The Hurt Locker. Mackie also narrated The Best That Never Was, a documentary about football player Marcus Dupree. He appeared in the 2011 film The Adjustment Bureau as Harry Mitchell, a sympathetic member of a shadowy supernatural group that controls human destiny. Mackie co-starred, as Sam Wilson / Falcon, in the Marvel Studios sequel Captain America: The Winter Soldier (2014). He reprised the role in multiple Marvel Cinematic Universe films over the next several years, including 2015's Avengers: Age of Ultron and Ant-Man, 2016's Captain America: Civil War, 2018's Avengers: Infinity War, and 2019's Avengers: Endgame.
In 2016, Mackie portrayed Martin Luther King Jr. in the HBO TV drama All the Way. In 2018, Mackie appeared as gang leader King in The Hate U Give, a film adaptation of the bestselling novel of the same name. In 2019, Mackie had a role in the Netflix science-fiction film, IO.
In July 2018, it was announced that Mackie was cast in the role of Takeshi Kovacs for the second season of Netflix's science-fiction series, Altered Carbon. In March 2019, it was announced that Mackie was cast in the fifth season of Netflix's science-fiction anthology series, Black Mirror. The following month, Disney confirmed a Marvel television series starring Mackie and Sebastian Stan, called The Falcon and the Winter Soldier, would be aired on their upcoming Disney+ streaming service, debuting on March 19, 2021. Mackie starred in and produced the science fiction film Outside the Wire which was released by Netflix on January 15, 2021. In August 2021, Mackie closed the deal to reprise the role in Captain America 4.
In January 2022, it was announced that Mackie will helm the drama film Spark, starring Saniyya Sidney, as his directorial debut project. In February 2022, he was set to lead action film Ending Things along with Priyanka Chopra Jonas, directed by Kevin Sullivan and star in a live-action series adaptation of Twisted Metal game at Peacock.